AKT1 and non-small cell lung carcinoma: Moreover, quercetin suppressed metastatic abilities of non-small cell lung cancer (NSCLC) and bone metastasis in an orthotopic A549 xenograft model and suppressed migratory and invasive abilities of A549 and HCC827 cells through the inhibition of Snail-dependent AKT activation and the Snail-independent disintegrin and metalloproteinase (ADAM) 9 expression pathway [73].