Wogonin, one of major flavonoids isolated from Scutellariae radix (Scutellaria baicalensis L.)reduced lipopolysaccharide (LPS)-induced invasiveness of MDA-MB-231 breast cancer cells through the downregulation of IL-8 and MMP-9 and their association with leukotriene B4 receptor 2 (BLT2)/extracellular signal-regulated kinase (ERK)-linked cascade. This evidence concerns the gene LTB4R2 and breast carcinoma.