Anti-metastatic properties of apigenin, mediated through direct targeting of SPOCK1 and an inactivation of Snail-Slug mediated EMT, were observed in PC-3, PC-3 M and DU145 prostate cancer cells in vitro and suppressed prostate cancer metastasis in vivo in PC-3 M-Luc mice [53]. This evidence concerns the gene SNAI2 and prostate cancer.