Myricetin suppressed lung metastases in the 4T1 mouse model in vivo as well as migration, invasion, and metastasis in the MDA-Mb-231Br breast cancer cell line in vitro by suppression of MMP-2/-9 protein expression as well as expression of ST6GALNAC5, which is specifically expressed in brain metastatic cell lines and upregulated in brain metastasis patients [78]. The gene discussed is MMP2; the disease is breast carcinoma.