For instance, while hypoalbuminemia did not have a significant effect on the displacing effect of IMA, only at a ratio of 1:5 (FLU/5-FU) a significant increase in unbound FLU (11.18% (25 g/L HSA) vs. −3.19% (40 g/L HSA)) was observed. Here, ALB is linked to Hypoalbuminemia.