The higher gene expression level of several cytokines, such as IL-1β, IL-12/IL-23p40, IL-17, IL-18 and TNFα was detected in RR-MS compared to HS, according to with the levels measured in the serum; this confirms the relationship between expression and production of pro-inflammatory cytokines in MS patients [35]. Here, IL18 is linked to myeloid sarcoma.