Even if cholinergic neurotransmission regulates the immune response and inhibits cytokine release after stroke, only the variant alleles of BChE have been identified as risk factors for ischemic stroke [54] and associated with reduced BChE activity in patients with post-stroke dementia (PSD) [49], while AChE rs1799806 do not influence the AChE activity. The gene discussed is ACHE; the disease is Stroke.