Since in translational research, using the most representative animal model to test new compounds is crucially important, the aim of this study was to describe BMPR2 receptor expression and downstream signaling in the MCT and SuHx rat model for experimentally induced PAH and to compare these findings to altered BMPR2 signaling in the lungs of iPAH and hPAH patients. This evidence concerns the gene BMPR2 and pulmonary arterial hypertension.