Another 5-HT receptor antagonist, terguride, reduces the pro-fibrotic potential in scleroderma and suppresses pathways implicated in the regulation of pro-fibrotic genes, suggesting that 5-HT inhibitors might reduce MF via suppression of TGF-β1-mediated non-canonical signaling pathways [110]. The gene discussed is TGFB1; the disease is scleroderma.