Interestingly, a recent study (Breast Cancer and Exercise Trial in Alberta) [44] by Friedenreich et al. also examined the effects of a year-long PA intervention on BCSs’ biomarkers, including C-reactive protein, insulin, glucose, homeostatic model assessment of insulin resistance, estrone, sex hormone-binding globulin, total estradiol, and free estradiol. This evidence concerns the gene SHBG and breast carcinoma.