TP53 and neoplasm: In these studies, different mice strains harboring equivalent human tumor p53-mut (e.g., p53273H, p53R248Q, p53R248W, p53175H and p53G245S) reported a shorter tumor latency, a wider tumor spectrum and a higher rate of metastasis, supporting the concept that p53-mut actively sustains cancer development and progression [13,17,27,28,29,30].