Successively, Shimada et al. detected, in 258 oesophageal cancer patients, that s-p53-Abs (p < 0.001; HR: 10.62; 95%CI:0.76-40.00) and serum C-reactive protein concentration (S-CRP) were independent prognostic factors [138]. The gene discussed is CRP; the disease is carcinoma of esophagus.