TP53 and cancer: The accumulation of p53 can be triggered by many mechanisms, such as stress signals, DNA damage, nucleotide deprivation, DNA damage, mitogenic or oncogenic activation viral infection, heat shock proteins like HSP70/HSP40/HSP90, which, in cancer cells, form a multi-chaperone complex around p53-mut facilitating the unfolding of the p53-mut and its spontaneous folding to another conformation with different energy minimum [58,59,60] (Figure 1).