Briefly, the following immune responses are influenced by the p53 status in tumors: (1) perturbations in the antigen presentation machinery, reducing immune escape [63]; (2) downregulation of natural killer group membrane D (NKG2D), which leads to cancer cells immune evasion [64]; (3) the regulation of immunosuppressive molecule programmed death ligand 1 (PD-L1) [65]; (4) the regulation of cytokines and chemokines [66]. The gene discussed is CD274; the disease is cancer.