Compared to mice in the AKI group, those treated with pFUS alone demonstrated a significant increase in body weight (22.29 ± 3.04 vs. 29.71 ± 9.15 g, p < 0.05) and non-significant increase in kidney weight (0.14 ± 0.02 vs. 0.18 ± 0.03 g, p > 0.05) (Figure 1A), a significant decrease in BUN (278.48 ± 37.29 vs. 164.33 ± 45.74 mg/dL, p < 0.05) and SCr (2.39 ± 0.07 vs. 1.43 ± 0.21 mg/dL, p < 0.05) (Figure 1B), and a significant decrease in serum KIM-1 (84.19 ± 8.96 vs. 45.95 ± 10.28 pg/mL, p < 0.05) and NGAL (4.14 ± 0.20 vs. 2.71 ± 0.56 pg/mL, p < 0.05) (Figure 1C). This evidence concerns the gene LCN2 and acute kidney injury.