CASP1 and peritonitis: On the contrary, intracellular HSP70 has also been shown to inhibit NLRP3 inflammasome activation in a mouse model of peritonitis [40], where HSP70 deficiency caused worsened NLRP3-dependent peritonitis and enhanced caspase-1 activation and IL-1β production by macrophages, while genetic or heat shock-induced HSP70 overexpression had the opposite effect.