These results were confirmed by Western blot: compared to the AKI group, IL-1β and IL-18 were suppressed by both EVs alone (IL-1β: 1.57 ± 0.10 vs. 0.48 ± 0.07 relative expression, p < 0.05; IL-18: 1.88 ± 0.10 vs. 0.98 ± 0.28 relative expression, p < 0.05) and pFUS alone (IL-1β: 1.57 ± 0.10 vs. 1.08 ± 0.07 relative expression, p < 0.05; IL-18: 1.88 ± 0.10 vs. 0.81 ± 0.40 relative expression, p < 0.05) (Figure 3B). Here, IL18 is linked to acute kidney injury.