NLRP3 and acute kidney injury: Compared to the AKI group, NLRP3 was suppressed in the kidneys by both EVs alone (1.42 ± 0.10 vs. 0.81 ± 0.41 normalized expression, p > 0.05) and pFUS alone (1.42 ± 0.10 vs. 0.47 ± 0.26 normalized expression, p < 0.05) (Figure 2A).