NOX2 is expressed in endosomes following different types of infection and its expression is dependent on Toll-like Receptor-7 (TLR-7), that binds double stranded RNA (dsRNA), a transitory intermediate formed during the replication of many RNA viruses, and TLR-9, that recognizes unmethylated CpG motifs within viral genome of DNA viruses [10]. This evidence concerns the gene CYBB and infection.