Studies on AD have revealed the aggregation of glial cells around the SP in the brain tissue of patients and AD rats, subsequently causing inflammation, and the abnormally elevated expression of inflammatory factors, including interleukin‐1 (IL‐1), IL‐6 and tumour necrosis factor‐α (TNF‐α), which further amplifies the inflammatory cascade.10, 11. This evidence concerns the gene TNF and Alzheimer disease.