TBC1D5 and Legionnaires' disease: Thus, JX2 is functionally similar to the RidL 131-kDa effector protein of Legionella pneumophila, the etiological agent of Legionnaires’ disease, which displaces TBC1D5 from the retromer complex (Bärlocher et al., 2017; Romano-Moreno et al., 2017; Yao et al., 2018).