Furthermore, NFIL3, c-Maf, and Blimp1 are all likely to be important drivers of anergy and immunosuppression because they were previously identified as regulators of Il10, Havcr2, Tigit, and/or Pdcd1 expression in either T cells suppressed by IL-27 (Chihara et al., 2018, Zhu et al., 2015) or TILs derived from acute myeloid leukemia patients (Zhu et al., 2017). Here, TIGIT is linked to acute myeloid leukemia.