CDC7 and cancer: CDC7 and DBF4 tend to be overexpressed in primary cancers and tumor cell lines, and their levels negatively correlate with patient prognosis (Bonte et al., 2008, Cheng et al., 2013, Clarke et al., 2009, Ghatalia et al., 2016, Hou et al., 2012, Jaafari-Ashkavandi et al., 2019, Kulkarni et al., 2009, Melling et al., 2015, Subramanian and Cohen, 2019, Zhuang et al., 2018).