MTOR and neoplasm: The correlation between PIK3CA and PTEN has been reported previously in EC in a cohort of cases from Japan [34] and might have clinical implications since a large study of a variety of solid tumours (mainly colorectal and ovarian) showed that patients with PIK3CA and/or PTEN mutations had a significantly greater partial response to PI3K/mTOR inhibition [35] compared to wt-tumours of these two genes.