With regard to pancreatic cancer, DNA methylation markers, cyclin-dependent kinase inhibitor 2A (CDKN2A/p16), ras-associated domain family member 1 (RASSF1A) and neuronal pentraxin 2 (NPTX2) in cfDNA are considered diagnostic markers. This evidence concerns the gene RASSF1 and familial pancreatic carcinoma.