Moreover, prognostic factors for OCSCC including surgical (reconstructive technique, tracheostomy) and clinical (body mass index, albumin and hematocrit levels, Human Papilloma Virus [HPV] and Epstein-Barr virus [EBV] infections) parameters, tumor histology (histologic type, perineural invasion, lymphovascular invasion, lymph node positivity), and tumor markers (Ki67, epidermal growth factor receptor [EGFR], interleukin-2) were not examined. This evidence concerns the gene EGFR and neoplasm.