In the verification phase, the circulating exosomal lncRNA-GC1 levels in patients with GC were significantly higher compared with those of patients with CAG, patients with IM, patients who were HP positive, and patients who were HP negative (t = 14.43, t = 16.38, t = 18.94, and t = 22.62; all P < .001) (Figure 3A). This evidence concerns the gene HP and gastric cancer.