When we further evaluated the diagnostic value of lncRNA-GC1 for early detection of GC, we found that the levels of circulating exosomal lncRNA-GC1 in patients with stages I or II GC were significantly upregulated compared with those in the HDs and patients with CAG or IM (stage I GC vs HDs, t = 21.15; stage I GC vs CAG, t = 10.93; stage I GC vs IM, t = 12.63; stage II GC vs HDs, t = 23.82; stage I GC vs CAG, t = 12.11; stage I GC vs IM, t = 13.93; all P < .001) (Figure 3C). Here, SOD2 is linked to gastric cancer.