The effect of ASO-ψ is specific to the CFTR c.3718-2477C>T splice mutation as ASO-ψ treatment of non-CF hBE cells and homozygous F508del-CFTR hBE cells had no effect on chloride secretion compared to the control (Supplementary Figures S3B, C; S4D, E). The gene discussed is CFTR; the disease is cystic fibrosis.