INS and cystic fibrosis: Cystic fibrosis (CF) is the most common genetic disease in Caucasians, beingcharacterized by multisystem clinical manifestations and requiring a complextherapeutic regimen, which may include the use of bronchodilators, mucolytics,antibiotics, vitamin supplements, enzyme replacement therapy (ETR), insulin and,more recently, protein modulators of Cystic Fibrosis Transmembrane ConductanceRegulator (CFTR).