Because we did not determine Akt and F-actin, the mechanism of AM and cytoskeletal rearrangement for PI3K/mTOR/RhoA pathway is unclear after the expressions of PI3K and mTOR were silenced, and their effect on interaction of mTORC1 and mTORC2 with RhoA is unclear in COPD. Here, MTOR is linked to chronic obstructive pulmonary disease.