IL6 and airway hyperresponsiveness: As demonstrated byRT-qPCR determination, PCGEM1 was lowly expressed in CVA patients and its expressionwas elevated after montelukast sodium treatment and in the valid cases of CVA.lncRNAs are able to regulate inflammation by mediating recognized inflammatorymediators including TNF-α, IL-1, IL-6, and IL-18, as well as cell adhesion moleculessuch as ICAM-1 and VCAM-1 (29).IL-3-producing basophils that could release IL-4, IL-6, and IL-13 triggeredexacerbation of airway hyperresponsiveness in a murine inflammatory model (30).