Accumulating evidence demonstrates that patients with severe COVID-19 suffer from the hyperinflammatory syndrome or cytokine storm syndrome, characterized by hypercytokinaemia, such as an increase in the levels of interleukin (IL)-1β, IL-2, Interferon γ-induced protein 10 (IP10), granulocyte colony-stimulating factor (GCSF), IL-7, interferon γ (IFNγ), monocyte chemotactic protein 1 (MCP1), macrophage Inflammatory Protein 1 α (MIP1α), and Tumor necrosis factor α (TNFα) (Chen et al., 2020a; Haberman et al., 2020; Koff and Williams, 2020; Mehta et al., 2020; Schett et al., 2020). The gene discussed is CSF3; the disease is COVID-19.