In this prospective, randomized, investigator-blinded, multiple-dose, multicenter, comparative, parallel-group study, safety and efficacy of test were compared with those of reference in Indian patients with active RA concomitant on MTX therapy, in terms of improvement in ACR 20, 50, 70, DAS 28 – CRP scores and HAQ-DI for efficacy assessments, treatment emergent immunogenicity and AEs for safety assessments over the period of treatment. This evidence concerns the gene CRP and rheumatoid arthritis.