ANK3 and Behcet disease: The lifetime prevalence of BD is approximately 2.4% worldwide with twin-h2 of 80%.65 GWAS of BD have suggested a highly polygenic architecture so far comprising of 30 distinct loci associated with BD susceptibility.66 The most replicated risk genes are ankyrin 3 (ANK3) and calcium voltage-gated channel subunit alpha1 C (CACNA1C).