Genetic risk for cannabis use was positively genetically correlated with MDD and SCZ, risk-taking behavior, and neuroticism.182 Age at cannabis initiation also appears to be moderately heritable, and the significant association with ATP2C2 is consistent with the role of calcium signaling mechanisms in the propensity to cannabis use.183 In a GWAS of cannabis dependence, there is a consistent overlap with potential genetic factors contributing to major depression and SCZ.184. The gene discussed is ATP2C2; the disease is major depressive disorder.