SOD1 and leukemia: Moreover, most of these genes were found related to complex diseases, for example, the most significant homozygous deletion of CFHR1 is associated with leukemia (Fratelli et al., 2016), APOA2 allelic imbalance is involved in endometrial cancer (Goumenou et al., 2001), and specific inhibition of SOD1 selectively promotes cancer cell apoptosis through regulating the ROS signaling network (Li et al., 2019).