PLIN2 and Glucose intolerance: In regard to glucose intolerance and lipid deposition induced by uridine accumulation, the down-regulated SDS would help to reduce gluconeogenesis and the up-regulated PLIN2 could boost lipid accumulation and lipid droplet formation, then transfer lipid droplet to blood and deliver it to hump to store fat by membrane envelopment of milk lipid globule-like secretion as the responsible regulation pathway.