The protein levels of SMC3, BUB1, STAG2, and THOC1 were further examined by western blotting, which suggested that WJT markedly reduced the expression of SMC3 and BUB1 in RA-FLSs after 3 mg/mL WJT treatment, and the expression of STAG2 and THOC1 were also significantly suppressed after 48 h (Fig. 6c, d). This evidence concerns the gene BUB1 and rheumatoid arthritis.