Group 1 (CD25+/CD123+) has higher incidence of CNS infiltration and lymphadenopathy, lower rate of induction remission response, and a higher number of Ph+, but lower concentration levels of serum LDH as compared to group 2 (single positive and double negative for CD25/CD123) (p = =0.01; 0.05; <0.001; <0.01, respectively). This evidence concerns the gene IL3RA and Lymphadenopathy.