ITGB4 knockdown at least partially rescued the promotion of ZKSCAN3 overexpression in HCC migration and invasion (P < 0.05, Fig. 4g) and EMT progress (P < 0.05, Fig. 4h), suggesting that ITGB4 was involved in ZKSCAN3-mediated migration and EMT process. Here, ZKSCAN3 is linked to hepatocellular carcinoma.