PIN1 and cancer: It is known that Wee1 protein kinase negatively regulates CDK1 activity by phosphorylating the Thr14 and Tyr15 residues of CDK1, while Pin1 binding to Wee1 can neutralize the inhibitory effect of Wee1 on CDK1 [122], enhance the activity of cyclin B1/CDK1 complex, regulate G2/M progression, and promote Pin1 in cell cycle control and cancer.