Yang et al. found that hypoxia-responsive manner of cZNF292 was independent of HIF1A and the knockdown cZNF292 in HCC SMMC7721 cells increased SRY (sex determining region Y)-box 9 (SOX9) nuclear translocation, which suppressed Wnt/β-catenin pathway and thereby inhibited cancer cell proliferation. The gene discussed is HIF1A; the disease is cancer.