Key to Rux efficacy is its broad anti-inflammatory activity against the myeloproliferative neoplasm (MPN) inherent cytokine storm with pro-inflammatory IL-1, IL-6, IL-8, IL-12, TNF-α, IFNγ, VEGF, TGFβ, FGF, PDGF, GM-CSF, and G-CSF cytokines/growth factors [11]. This evidence concerns the gene TNF and myeloproliferative neoplasm.