EGR3 and neoplasm: The mean EGR3 staining intensity in peripheral EGR3 + tumour cells (mean intensity = 172.7 AU) significantly increased by 13.8% when compared to central tumour cells (mean intensity = 151.8 AU, P = 0.04), indicating that peripheral tumour cells had higher expression of EGR3 protein compared to central tumour cells (Fig. 2H).