The remaining 8 pathways related to human disease (tuberculosis and human papillomavirus infection), metabolism (arginine and proline metabolism, photosynthesis, steroid biosynthesis, and photosynthesis - antenna proteins) environmental information processing (cell adhesion molecules (CAMs)) and organismal systems (parathyroid hormone synthesis, secretion and action) were significantly enriched in the Billing’s reservoir (Supplementary Table S3). This evidence concerns the gene PTH and human papilloma virus infection.