MAP1A and cancer: It would be premature to speculate on the mechanistic basis for this dysregulation, as MDA-MB-231 is a highly divergent cancer cell line, with 2948 genes showing altered copy number and 946 genes showing altered expression36; however, some of these can be linked to NMDARs and Ca2+ signalling, e.g. an NMDAR-anchoring protein Map1A and a number of calmodulin-like proteins.