ENHO and steatosis: A recent study conducted on mice with induced nonalcoholic steatohepatosis showed that knockout of adropin significantly exacerbated steatosis, inflammation and fibrosis while on the other hand intraperitoneal administration of adropin led to reduced expression of inflammation genes and upregulated nuclear factor erythroid 2-related factor 2 (Nrf2)40, one of the most prominent regulators of cellular resistance to oxidative stress41.