Similarly, the rs2760524 risk allele (G) is associated with lower expression of the regulator of G protein signaling 1 (RGS1) gene in monocytes of both MS cases and healthy controls; however, the effect of this allele is smaller in MS cases (P = 0.002 for genotype–phenotype interaction, FDR q = 0.1 after adjustment for multiple testing of 71 SNP–gene pairs in monocytes, Fig 2A). The gene discussed is RGS1; the disease is myeloid sarcoma.