The present study implements the pipeline designed to the collapsing the list of differentially expressed in MI genes into a diagnostic signature; the obtained robust classification model includes ADAP2, KLRC1, MIR21, PDGFD and CD14 genes and is enable classifying MI patients and healthy controls with a quality of 0.911 on an independent test data. Here, MIR21 is linked to myocardial infarction.