In previous reports in adult patients with HLH, one study associated hypofibrinogenemia (≤150 mg/dl), fibrinogen ≤200 mg/dl (P = 0.04), and prothrombin time > 50% with increased mortality [23], while another showed that patients with disseminated intravascular coagulation, nosocomial infections and neurological symptoms had a statistically significant worse survival [23]. Here, F2 is linked to Disseminated intravascular coagulation.