Previously, our group identified an episignature of human colorectal cancer associated with obesity and demonstrated that methylation of T cell lymphoma invasion and metastasis 1 (TIAM1), Zinc finger protein type 397OS (ZNF397OS), and 543 (ZNF543) genes represented the top genes scoring, associated with colorectal cancer and an increased body mass index (BMI) in two independent cohorts [24]. The gene discussed is TIAM1; the disease is colorectal cancer.