PPARGC1A and colorectal carcinoma: In order to determine the role of SFRP2 methylation in VAT and CRC, we studied the relationship between key genes in adipose tissue, implicated in adipogenesis as CCAAT/enhancer-binding protein alpha (C/EBPα), peroxisome proliferator activated receptor gamma (PPARγ), peroxisome proliferator activated receptor gamma coactivator 1 alpha (PGC1α), and inflammatory processes, as nuclear factor kappa B (NFκB) and tumor necrosis factor alpha (TNFα) and vitamin D receptor (VDR) (Fig. 4).