We have previously shown that clearing sMIC with B10G5, a nonblocking anti-sMIC antibody, can restore NK cell homeostatic maintenance and function [18], alleviate the immune-suppressive tumor microenvironment by eliminating arginase I+ MDSCs and tumor-associated macrophages [17], stabilize CD3ζ expression on CD8 T cells [28], and enhance CD28-NKG2D dual co-stimulation to antigen-specific CD8 T cells [38]. The gene discussed is CD28; the disease is neoplasm.