Soluble human NKG2D ligands have been shown to subvert antitumor immunity through multiple mechanisms, including but not limited to, perturbing NK cell homeostatic maintenance and function, impairing CD8 T cell function by destabilizing CD3ζ [16], and expanding myeloid-derived suppressive cells (MDSCs) in the tumor microenvironment [17]. Here, KLRK1 is linked to neoplasm.