Experiments were performed to ascertain the effects of PAR4 and RGS proteins on several genes related to colon cancer progression, including activating transcription factor 3 (ATF3), cyclooxygenase 2 (COX2), basic transcription factor 3 (BTF3), SNAIL1, zinc finger protein 91 (ZFP91), liver receptor homolog 1 (LRH1), specificity protein 1 (Sp1), and p21. This evidence concerns the gene F2RL3 and malignant colon neoplasm.