Previous works reveal that the NLRP3 inflammasome contributes to the pathogenesis of a number of neurodegenerative diseases including Alzheimer’s (Heneka et al. 2014; Walsh et al. 2014; Zhang and Jiang 2015), Parkinson’s disease (Franchi et al. 2010; Amor et al. 2014; Yan et al. 2015) and Multiple Sclerosis (MS) (Jha et al. 2010; Guo et al. 2015; Weinberg et al. 2015; Yeung et al. 2015; Matthews et al. 2016). This evidence concerns the gene NLRP3 and myeloid sarcoma.