IFNA1 and COVID-19: Following this reasoning, the capacity of silibinin to reduce viral loads in non-IFN responders along with its recognized ability to exert direct anti-viral effects against flaviviruses (HCV and dengue virus), togaviruses (Chikungunya virus and Mayaro virus), influenza virus, human immunodeficiency virus, and HBV [112], might be considered to develop prophylactic interventions in individuals facing significant risk of developing COVID-19 (e.g., close contacts, households, and healthcare workers).