ACE2 and infection: Intriguingly, however, it has recently been discovered that ACE2, the entry receptor of SARS-CoV-2, is a previously unrecognized human ISG in airway epithelial cells, thereby suggesting that SARS-CoV-2 might exploit species-specific IFN/STAT-driven upregulation of ACE2—a tissue-protective mediator during lung injury—to enhance infection [78].