The T2DM patients were treated with various anti hyperglycemic drugs (15 patients used insulin with various dosing regimens, either with or without other antihyperglycemic drugs, 7 patients were treated with metformin monotherapy, 4 with sulfonylourea monotherapy and one person was treated with the combination of metformin and gliclazide). Here, INS is linked to type 2 diabetes mellitus.