In general, whenever possible, young patients diagnosed with renal tumors should benefit from genetic counseling and testing (Chromophobe-RCC is associated with Birt-Hogg-Dubé syndrome, 10% of clear-cell RCC harbor Xp11.2/TFE3 translocation) [20]. The gene discussed is TFE3; the disease is Birt-Hogg-Dubé syndrome.