In summary, RSU1 is a focal adhesion protein that seems to play a tumor suppressor role in breast cancer [48,69,74], liver cancer [76] and glioblastoma [80,84], although its involvement in the regulation of cell migration and invasion in vitro in breast, liver and brain cancer cells also suggests cell-type specific metastatic promoting functions. The gene discussed is RSU1; the disease is glioblastoma.