MMP13 and central nervous system cancer: On the contrary, RSU-1 silencing was shown to inhibit migration and invasion of aggressive cells and promote those of less aggressive cells [80], indicating that RSU1 promotes the invasion capacity of aggressive glioma cells A172 and U87-MG that express high levels of RSU1. This was achieved through activation of Signal Transducer and Activator of Transcription (STAT6) and MMP-13, while the inhibition of cell invasion in less aggressive H4 and SW1088 glioma cells, which express RSU1 in low levels, was also observed to take place through negative regulation of STAT6 and MMP13 [80].