MGMT and cancer: For example, epigallocatechin-3-gallate, the main catechin from green tea, through the inhibition of DNMTs, allows the expression of tumor suppressor genes, including p16, retinoic acid receptor beta (RARβ), glutathione S-transferase pi (GSTP) and methylguanine-DNA methyltransferase (MGMT) in several human cancer cell lines [263].