VEGFA and plasma cell myeloma: Sorafenib, a multi-kinase inhibitor that acts predominantly through inhibition of Raf-kinase and VEGF receptor 2 (Figure 3), affects the BM microenvironment and its interaction with myeloma cells by inhibition of VEGF-induced tubule formation and downregulation of VEGF and IL-6 secretion [162,163,167].