In colon cancer, expression profile of immune-related genes (e.g., IFNG, IL15, GNLY, CCL3, CXCL16) together with infiltration of the tumor with cytotoxic and memory lymphocytes (“Immunoscore“) are prognostic factors independently of the presence of microsatellite instability (MSC) [64]. The gene discussed is IFNG; the disease is neoplasm.